The association between gastric cancer and sarcopenia: a scoping review
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View abstract on PubMed
Summary
This summary is machine-generated.Sarcopenia, or muscle loss, is highly prevalent in gastric cancer patients and predicts poor outcomes. Preserving muscle mass is crucial for improving survival and prognosis after surgery.
Area Of Science
- Oncology
- Geriatrics
- Nutrition Science
Background
- Sarcopenia is a growing concern in oncology, particularly in gastric cancer patients.
- Understanding the relationship between sarcopenia and gastric cancer is crucial for improving patient outcomes.
Purpose Of The Study
- To explore the relationship between gastric cancer and sarcopenia.
- To review the underlying mechanisms linking sarcopenia and gastric cancer.
- To assess the prognostic implications of sarcopenia in gastric cancer.
Main Methods
- Systematic literature search across multiple databases (Web of Science, PubMed, Cochrane, CNKI, Wanfang, VIP).
- Included 33 cohort studies (10,679 participants) following PRISMA-ScR guidelines.
- Assessed methodological quality using Joanna Briggs Institute (JBI) Critical Appraisal Tools.
Main Results
- Sarcopenia prevalence in gastric cancer patients ranged from 6.8% to 72.22%.
- Reduced muscle mass independently predicted postoperative complications, overall survival, and disease-free survival.
- Two studies found no significant impact of sarcopenia on survival due to heterogeneity in assessment.
Conclusions
- Postoperative sarcopenia is prevalent and predicts adverse outcomes in gastric cancer.
- Muscle mass preservation and preoperative assessment are vital for patient management.
- Standardized diagnostic criteria and mechanistic studies are needed for future research.
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