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Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis
1Department of Internal Medicine, Xianju Hospital of Traditional Chinese Medicine, Taizhou, Zhejiang, China.
Background:
This study aimed to explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis.
Methods:
PubMed, Embase, Web of Science, and Cochrane Library were searched for case-control/cohort studies on the occurrence of osteonecrosis in patients with systemic lupus erythematosus from the time the database was created until 1 December 2024. Data were analyzed using Stata 15.0, and the quality of the included studies was evaluated using the NOS score.
Result:
A total of 14 articles, including 3,890 patients, were included in the study, and the meta-analysis indicates that younger age in SLE patients [SMD = -0.23, 95% CI (-0.39, -0.06)], diabetes mellitus [OR = 1.78, 95% CI (1.03, 3.09)], hypertension [OR = 1.33, 95% CI (1.03, 1.72)], arthritis [OR = 1.57, 95% CI (1.24, 2.00)], Raynaud's phenomenon [OR = 1.76, 95% CI (1.35, 2.30)], and cyclophosphamide use [OR = 2.24, 95% CI (1.38, 3.63)] are risk factors for the development of osteonecrosis in patients with SLE.
Conclusion:
The current study found that younger age, hypertension, diabetes, arthritis, Raynaud's phenomenon, and cyclophosphamide use are independent risk factors for the development of osteonecrosis in patients with SLE.
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