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Related Experiment Video

Updated: Jan 12, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Engineering Multifunctional Nanozymes to Reprogram Oxidative Stress and Inflammation in Chronic Wounds.

Qingyan Li¹, Weilin Zheng², Jingge Cheng¹

¹Emergency and Disaster Medicine center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, People's Republic of China.

International Journal of Nanomedicine

|November 3, 2025

Summary

This study introduces Ru@ACEI, a novel nanosystem that accelerates diabetic wound healing. By reducing inflammation and promoting cell survival, it offers a promising therapeutic strategy for chronic wounds.

Keywords:

ROS-scavenge anti-inflammatory microenvironment apoptosis diabetic wound nanoenzyme

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Published on: February 28, 2025

Area of Science:

Biomaterials Science
Nanotechnology
Wound Healing Research

Background:

Diabetic wounds present a significant global health challenge due to immune dysregulation and chronic inflammation, impairing healing.
Persistent inflammation and oxidative stress exacerbate tissue damage in diabetic wounds, leading to delayed or non-healing outcomes.

Purpose of the Study:

To develop and evaluate a novel composite nanosystem, Ru@ACEI, for enhanced diabetic wound healing.
To investigate the anti-inflammatory and pro-healing effects of Ru@ACEI nanoparticles in a preclinical model.

Main Methods:

A composite nanosystem (Ru@ACEI) was engineered using ruthenium-incorporated hollow mesoporous silica nanoparticles loaded with angiotensin-converting enzyme inhibitors (ACEIs).
The nanoparticles' dual enzyme-mimetic activities (superoxide dismutase and catalase) were assessed for reactive oxygen species (ROS) scavenging capabilities.
The impact of Ru@ACEI on cellular apoptosis, endothelial cell proliferation, and inflammatory pathways (NLRP3/Caspase) was evaluated.

Main Results:

Ru@ACEI nanoparticles effectively scavenged excess ROS, reducing cellular apoptosis and promoting endothelial cell proliferation.
The nanosystem suppressed the NLRP3/Caspase-3/Caspase-9 apoptosis pathway, enhancing endothelial cell survival.
Ru@ACEI significantly mitigated local hyperinflammation and improved diabetic wound healing by reducing pro-inflammatory factors.

Conclusions:

The Ru@ACEI nanosystem demonstrates significant potential in accelerating diabetic wound healing.
By modulating the inflammatory microenvironment and promoting cell survival, Ru@ACEI offers a promising therapeutic strategy for chronic diabetic wounds.