T-Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation for Relapsed B-Cell Precursor Acute...

Recurrent acute lymphoblastic leukemia (ALL) following chimeric antigen receptor T-cell (CAR-T) therapy represents a significant therapeutic challenge, particularly in pediatric populations. This report describes three cases of B-cell precursor ALL that recurred after CAR-T therapy and were successfully treated with T-cell-replete haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT). This approach has shown promising outcomes in terms of long-term survival, highlighting the potential of TCR-haplo-HSCT as consolidation therapy for recurrent pediatric ALL post-CAR-T therapy.