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Cerebellar dysfunction in glaucoma patients
Anisha Kasi1,2, Ji Won Bang1,3, Vivek Trivedi1
1New York University Grossman School of Medicine, NYU Langone Health, New York University, New York, NY 10017, USA.
Brain Communications
|November 3, 2025
Summary
Glaucoma patients show weakened cerebellar connectivity, impacting balance. Brain-wide changes, including the cerebellum, may explain fall risks in glaucoma.
Area of Science:
- Neuroscience
- Ophthalmology
- Gerontology
Background:
- Glaucoma patients exhibit increased fall rates compared to healthy older adults.
- Neural mechanisms underlying impaired balance in glaucoma are not well understood.
- Cerebral changes in glaucoma extend beyond visual pathways, but cerebellar involvement is unclear.
Purpose of the Study:
- To investigate alterations in cerebellar functional connectivity in glaucoma patients.
- To compare brain functional connectivity between glaucoma subjects and healthy controls.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) at 3 Tesla.
- Comparison of 32 glaucoma patients and 10 age-matched healthy controls.
- Regions-of-interest and seed-to-voxel analyses of cerebellar connectivity.
Main Results:
- Glaucoma patients demonstrated reduced functional connectivity within the cerebellum.
- Altered functional connectivity was observed between cerebral and cerebellar regions in glaucoma patients.
- Findings suggest widespread brain changes affecting the cerebellum in glaucoma.
Conclusions:
- Cerebellar dysfunction may contribute to impaired postural and cognitive control in glaucoma.
- Cerebro-cerebellar alterations are implicated in the neural basis of balance deficits in glaucoma.
- Glaucoma involves brain changes extending to the cerebellum, potentially explaining balance issues.
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