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Related Experiment Video

Updated: Jan 12, 2026

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
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Total Ankle Replacement in Hemophilia.

E Carlos Rodriguez-Merchan

    The Archives of Bone and Joint Surgery
    |November 3, 2025
    PubMed
    Summary

    Total ankle replacement (TAR) in people with hemophilia (PWH) shows improved pain and function but has an 8.8% complication rate. Long-term survival is estimated at 92.2%, with outcomes similar to ankle fusion.

    Area of Science:

    • Orthopedic Surgery
    • Hematology

    Background:

    • Hemophilia is a genetic bleeding disorder impacting joint health.
    • Total ankle replacement (TAR) is a surgical option for severe ankle arthritis.

    Purpose of the Study:

    • To review the current literature on total ankle replacement (TAR) in people with hemophilia (PWH).

    Main Methods:

    • Literature search of PubMed using keywords 'hemophilia' and 'total ankle replacement'.
    • Analysis of 8 papers reporting on 136 TARs in 103 PWH.

    Main Results:

    • TAR improved preoperative pain and function in PWH.
    • Complication rate was 8.8% (fractures, wound healing issues, hematomas).
    • 5.1% of TARs required additional surgery; estimated 10-year survival free of removal/fusion was 92.2%.
    Keywords:
    AnkleAnkle fusionHemophiliaHemophilic arthropathyTotal ankle replacement

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    Conclusions:

    • TAR offers pain relief and functional improvement for PWH with ankle arthritis.
    • While complications exist, TAR shows promising long-term survival.
    • Outcomes and adverse events are comparable between TAR and ankle fusion in PWH.