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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Impact of antiphospholipid and antinuclear antibodies in coronary artery disease progression

Tamara Garcia-Camarero1, Víctor M Martínez-Taboada2,3, Juan Irure4

  • 1Department of Cardiology, Hospital Marqués de Valdecilla- IDIVAL, Santander, Spain.

Frontiers in Immunology
|November 3, 2025
PubMed

Insights

Antiphospholipid (aPL) and antinuclear antibodies (ANA) do not appear to significantly impact coronary artery disease (CAD) progression. Further research is needed to confirm these findings in larger studies.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Autoimmunity

Background:

  • The association between antiphospholipid antibodies (aPL) and antinuclear antibodies (ANA) with coronary artery disease (CAD) progression is not well-established.
  • Understanding these links is crucial for predicting CAD outcomes.

Purpose of the Study:

  • To investigate whether the presence of aPL or ANA predicts the progression of coronary artery disease (CAD).

Main Methods:

  • A retrospective case-control study involving 180 CAD patients (rapid clinical progressors and long-standing stable) and 210 controls.
  • Analysis of autoantibodies including anticardiolipin (aCL), anti-β2 glycoprotein I (aB2GPI), anti-phosphatidylserine/prothrombin (anti-PS/PT), and ANA.

Main Results:

  • CAD patients showed higher aCL positivity compared to controls.
  • A significant increase in aCL IgA was observed in rapid clinical progressors versus long-standing stable patients.
  • No consistent differences in ANA or other autoantibodies were found between patient groups.

Conclusions:

  • Current evidence does not support a significant role for aPL or ANA in the development or progression of CAD.
  • Findings are hypothesis-generating, necessitating larger, prospective multicenter studies for definitive conclusions.
Abstract

Keywords:
antinuclear antibodiesantiphospholipid antibodiesantiphospholipid syndromecoronary artery diseasemyocardial infarction

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