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Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
Published on: August 19, 2025
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Circadian system and aging: where both times interact.
Claudia García Cobarro1, Lara Ignez Soares1, Yevheniy Kutsenko1
1Department of Physiology, Circadian Rhythm and Cancer Laboratory, Biomedical Research Institute of Murcia Pascual Parrilla-IMIB, Murcia University, Murcia, Spain.
Frontiers in Aging
|November 3, 2025
Summary
Circadian rhythms, or daily biological cycles, deteriorate with age, impacting healthspan. Restoring these rhythms may offer strategies to promote healthy aging and resilience.
Area of Science:
- Chronobiology
- Gerontology
- Molecular Biology
Background:
- Time influences life through aging and biological rhythms, leading to the concept of circadian aging.
- Circadian clocks, essential for physiology, evolved early and are complex in mammals, involving multiple oscillators and environmental cues.
- Aging impairs circadian function, contributing to metabolic, cognitive, immune, and sleep issues.
Purpose of the Study:
- To explore the interplay between circadian time and chronological time in aging.
- To examine age-related changes in circadian rhythms and their molecular underpinnings.
- To highlight potential chrono-geroprotective strategies based on circadian interventions.
Main Methods:
- Review of literature on circadian rhythms and aging.
- Analysis of molecular crosstalk between clock genes and aging pathways.
- Examination of species with negligible senescence and their circadian robustness.
Main Results:
- Circadian function declines with age, correlating with aging hallmarks.
- Species with negligible senescence often maintain robust circadian rhythms.
- Molecular pathways link circadian regulation and aging processes.
Conclusions:
- Circadian aging is an emerging concept linking biological rhythms and senescence.
- Temporal homeostasis is a potential marker and modulator of healthy aging.
- Circadian interventions show promise for enhancing healthspan and resilience.
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