Related Experiment Video
Updated: Jan 12, 2026
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Correlation of Modified CT Severity Index (MCTSI) and serum lipase levels in assessing acute pancreatitis severity: a
Prabin Pandey1, Bikash Raj Thapa1, Saroj Sharma1
1Department of Radiology, National Academy of Medical Science, Kathmandu, Nepal.
Background:
Acute pancreatitis is a common gastrointestinal emergency requiring rapid assessment of severity. This study aimed to evaluate the association between Modified Computed Tomography Severity Index (MCTSI) and serum lipase levels, exploring whether lipase may serve as a surrogate marker of severity in settings where computed tomography (CT) is not readily available.
Method:
This prospective observational cohort study included 63 patients with acute pancreatitis who underwent contrast-enhanced CT and serum lipase testing between March 2024 and February 2025 at Bir Hospital. Patients were followed for clinical findings, length of hospitalization, ICU admission, and in-hospital mortality. MCTSI was calculated by two radiologists independently.
Result:
Moderately severe acute pancreatitis (MCTSI 4-6) was observed in 41.3% of patients. Mean serum lipase was 1789.9 U/L, with a strong positive association with MCTSI (rho = 0.793, P < 0.0001). Patients with severe MCTSI (scores 8-10) had significantly higher lipase levels (3204 ± 459 U/L) and longer hospital stays. Lipase ≥2160 U/L predicted severe acute pancreatitis with 95.2% sensitivity and 83.3% specificity (area under the curve = 0.946).
Conclusion:
Serum lipase levels correlate significantly with MCTSI-based severity and hospital outcomes in acute pancreatitis. Lipase may serve as a useful surrogate marker in settings without CT access. Further multicenter studies are warranted.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT