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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 1

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Published on: April 8, 2009

Characterization of Human Sertoli Cells Infected With Monkeypox Virus.

Yongyang Sun^1,2, Lina Liu³, Zhenjun Wang³

¹College of Veterinary Medicine, Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases, Ministry of Education, Jilin Agricultural University, Changchun, China.

Journal of Medical Virology

|November 3, 2025

Summary

This summary is machine-generated.

Monkeypox virus (MPXV) infects human Sertoli cells in the testis, causing cellular damage and viral replication. The study reveals MPXV disrupts immune responses and cell cycle, potentially explaining severe MPXV complications.

Keywords:

Sertoli cells monkeypox virus testis

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Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Single-cell Quantitation of mRNA and Surface Protein Expression in Simian Immunodeficiency Virus-infected CD4+ T Cells Isolated from Rhesus macaques

Published on: September 25, 2018

Area of Science:

Virology
Immunology
Cell Biology

Background:

The 2022 monkeypox (MPXV) outbreak highlighted sexual transmission routes.
The impact of MPXV on testicular cells and the subsequent immune response are not well understood.

Purpose of the Study:

To investigate MPXV susceptibility in human Sertoli cells.
To analyze the host gene expression profile following MPXV infection in these cells.

Main Methods:

MPXV inoculation of human Sertoli cells.
Viral load quantification.
Transmission electron microscopy (TEM).
Transcriptomic sequencing.

Main Results:

MPXV causes lesions and replicates within Sertoli cells, forming viral factories.
Viral particles are released via exocytosis.
Upregulation of stress, inflammation, and cell cycle genes observed.
Suppression of antiviral genes and high expression of interferon receptor-related genes.

Conclusions:

MPXV infects human Sertoli cells, detailing the host response at a cellular level.
Findings provide mechanistic insights into MPXV-induced epididymo-orchitis.
Results guide further in-vivo studies for MPXV pathogenesis.