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A Polydopamine-Modified DNA Origami Nanosystem for Photothermal-Chemical Combined Cancer Therapy
Ni Yang1, Meizhou Zhang2,3, Yeqing Gong2
1Department of General Practice, Huazhong University of Science and Technology, Tongji Hospital of Tongji Medical College,1095 Jiefang Avenue, Wuhan 430030, People's Republic of China.
ACS Applied Materials & Interfaces
|November 3, 2025
Summary
Researchers developed a novel DNA origami nanocarrier for cancer therapy. This platform precisely controls polydopamine nanomaterial formation, enabling combined photothermal and chemotherapy for enhanced tumor cell killing.
Area of Science:
- Nanomedicine
- Biotechnology
- Materials Science
Background:
- Polydopamine (PDA) is a photothermal agent for cancer therapy but suffers from uncontrollable polymerization, hindering nanomaterial functionalization.
- DNA origami offers precise nanoscale fabrication, enabling programmable control over material assembly and surface modification.
Purpose of the Study:
- To controllably fabricate polydopamine nanomaterials with specific morphologies using DNA origami.
- To develop a multifunctional nanocarrier for combined photothermal and chemotherapy in cancer treatment.
Main Methods:
- Utilized DNA origami technology for site-specific fabrication of polydopamine nanomaterials.
- Incorporated Doxorubicin (Dox) into the DNA origami structure for combined therapy.
- Evaluated the nanocarrier's efficacy in delivering polydopamine and Dox for tumor cell killing.
Main Results:
- Successfully fabricated DNA origami-templated polydopamine nanomaterials with preserved DNA origami functionality.
- Demonstrated the nanocarrier's capacity for site-specific drug delivery and photothermal conversion.
- Confirmed the synergistic effect of photothermal therapy and chemotherapy in effectively killing cancer cells.
Conclusions:
- Developed a versatile DNA origami-based nanocarrier for combined photothermal-chemotherapy.
- This strategy overcomes polydopamine's polymerization limitations, enabling precise fabrication and enhanced therapeutic outcomes.
- The findings highlight the potential of DNA nanostructures in advancing nanomedicine for cancer treatment.
