Related Experiment Video

Updated: Jan 12, 2026

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR
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MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

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Retraction Note: miR-564 inhibited metastasis and proliferation of prostate cancer by targeting MLLT3

F-J Meng1, F-M Meng, H-X Wu

  • 1Laboratory Medicine, Yidu Central Hospital of Weifang City, Weifang, Shandong, China.

European Review for Medical and Pharmacological Sciences
|November 3, 2025
PubMed

Insights

This study on prostate cancer has been retracted due to data inaccuracies and figure inconsistencies. The article investigated microRNA-564's role in inhibiting cancer metastasis and proliferation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Prostate cancer is a leading cause of cancer-related mortality globally.
  • MicroRNAs (miRNAs) play crucial roles in cancer development and progression.
  • MLLT3 has been implicated in various cancers, including prostate cancer.

Purpose of the Study:

  • To investigate the role of microRNA-564 (miR-564) in prostate cancer.
  • To determine if miR-564 affects metastasis and proliferation of prostate cancer cells.
  • To identify MLLT3 as a potential target of miR-564 in prostate cancer.

Main Methods:

  • The study utilized cell lines and molecular biology techniques.
  • Methods included assessing cell proliferation, migration, and invasion assays.
  • Western blot analysis was performed to evaluate protein expression levels.

Main Results:

  • miR-564 was found to inhibit prostate cancer cell metastasis and proliferation.
  • MLLT3 was identified as a direct target of miR-564.
  • Downregulation of miR-564 was associated with increased MLLT3 expression.

Conclusions:

  • miR-564 acts as a tumor suppressor in prostate cancer.
  • Targeting MLLT3 by miR-564 offers a potential therapeutic strategy.
  • Further research is warranted to explore the clinical applications of miR-564 in prostate cancer treatment.

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