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Updated: Jan 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[Medical Practice, Epidemiology, and Evidence-Based Medicine: A necessary triangle in healthcare]
Alfonso Vallejos-Parás1, David Alejandro Cabrera-Gaytán1, Porfirio Felipe Hernández-Bautista2
1Instituto Mexicano del Seguro Social, Coordinación de Vigilancia Epidemiológica, División de Vigilancia Epidemiológica de Enfermedades Transmisibles. Ciudad de México, México.
Abstract:
Today's healthcare faces complex challenges that require a comprehensive approach based on the best available evidence. Evidence-based medicine has influenced modern medicine and has been adopted as an element of scientific rigor. Meanwhile, medical practice, which has been based on theoretical reasoning, favouring the observation of patients without systematizing clinical experience, has shaped modern clinical practice with a relationship with research and epidemiology. It has contributed to the characterization of diseases and guidelines for their prevention and control. The combination of medical practice, epidemiology, and evidence-based medicine not only improves the quality of care but also optimizes clinical decision-making and strengthens public health policies. However, in daily practice, these areas are not always effectively integrated. This article addresses the need to consolidate this fundamental triangle to improve medical and public health care, with the challenging integration of information technologies.
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