Decoding noncoding RNAs in regulating cardiovascular aging and age-related conditions: the emerging landscape

Area of Science:

• Biomedical Sciences
• Molecular Biology
• Cardiology

Background:

• Cardiovascular disease (CVD) is a leading global cause of death.
• Cardiovascular aging (CVA) contributes to systemic aging and exacerbates CVDs.
• Non-coding RNAs (ncRNAs) are implicated in CVA and associated CVDs (AR-CVDs).

Purpose of the Study:

• To review the current understanding of ncRNAs in CVA and AR-CVDs.
• To explore the diverse roles of miRNAs, lncRNAs, and circRNAs in cardiovascular aging.
• To provide a holistic perspective on ncRNA regulation in aging and cardiovascular health.

Main Methods:

• Review of published studies on ncRNAs in aging and cardiovascular disease models.
• Analysis of in vitro and in vivo data on ncRNA functions.
• Integration of findings on miRNAs, lncRNAs, and circRNAs in CVA and AR-CVDs.

Main Results:

• ncRNAs act as pro-aging, anti-aging, or dual regulators in CVA.
• ncRNAs modulate vascular and cardiac aging through specific substrates and triggers.
• ncRNAs contribute to senescence and phenotypes like hypertension, atherosclerosis, and heart failure.

Conclusions:

• ncRNAs play significant regulatory roles in CVA and AR-CVDs.
• Understanding ncRNA networks offers insights into aging cardiovascular pathophysiology.
• Further research into ncRNAs may lead to novel therapeutic strategies for AR-CVDs.