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Updated: Jan 12, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-Catalyzed C(sp2)-H Activation Using Pyridine and Imidazopyridine as Directing Groups for Selective
Shengzhou Jin1, Shuo Bai1, Yu Wang2
1Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China.
Abstract:
Ruthenium-catalyzed C(sp2)-H activation using pyridine and imidazopyridine directing groups enables direct ortho-silylation of 2-arylimidazoheterocycles with hydrosilanes as silylation reagents. This method achieves regioselective C(sp2)-H silylation without the need for preactivation, affording ortho-silylated arylimidazo[1,2-a]pyridines in high yields. Notably, this represents the first example of hydrosilane coupling with imidazo[1,2-a]pyridines via pentacyclometalated intermediates. The scalable protocol is compatible with a broad range of 2-aryl nitrogen-containing heterocycles. Experimental studies support the proposed catalytic cycle, and downstream derivatization reactions highlight the synthetic utility of the products. Furthermore, long-term cycling tests of NCM811||Li cells demonstrate that the silylated product, used as an electrolyte additive, significantly improves the cathode-electrolyte interfacial stability.
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