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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Diabetic Peripheral Neuropathy, Diabetic Foot Ulcers and Selenium: A mini Review.

Elisavet E Pyrgioti1, Nikolaos D Karakousis2, Dimitrios S Karagiannakis3

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The International Journal of Lower Extremity Wounds
|November 3, 2025
PubMed
Summary

Low selenium levels may be linked to diabetic foot ulcers and neuropathy in type 2 diabetes. Further research is needed to confirm this association between selenium and diabetes complications.

Keywords:
diabetic footdiabetic foot ulcersdiabetic peripheral neuropathyoxidative stressselenium

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Nutritional Science

Background:

  • Diabetic foot ulcers (DFUs) and diabetic peripheral neuropathy (DPN) are serious complications of type 2 diabetes mellitus (T2DM).
  • Selenium (Se) is an essential trace element with antioxidant properties vital for human health.
  • Understanding factors influencing DPN and DFUs is crucial for managing T2DM.

Purpose of the Study:

  • To review the existing evidence on the potential relationship between selenium levels and the occurrence of DPN and DFUs.
  • To summarize findings from studies investigating selenium status in individuals with T2DM complications.

Main Methods:

  • This is a narrative mini-review.
  • The review synthesizes findings from limited available studies examining serum and urinary selenium levels in patients with DPN and DFUs.

Main Results:

  • Most studies indicated significantly lower serum selenium levels in individuals with DPN or DFUs compared to controls.
  • One study reported lower urinary selenium levels in the DPN group.
  • The available evidence is preliminary due to the limited number of studies.

Conclusions:

  • Preliminary evidence suggests a potential association between lower selenium levels and the presence of DPN and DFUs in T2DM patients.
  • Further comprehensive investigations are required to establish a definitive link and understand the role of selenium in these diabetic complications.