Healthy aging in midlife and menopausal transition in Asia: nutrient synergy with dietary supplements

Women in early midlife often experience specific health issues due to aging and the menopausal transition. Hormonal changes, systemic chronic inflammation and micronutrient deficiencies contribute to symptoms such as vasomotor disturbances, metabolic syndrome, neurocognitive decline and reduced mobility, which can adversely affect overall health and quality of life. However, the menopausal transition also offers opportunities for improving health and preventing diseases. Many women use dietary supplements as a form of complementary and alternative medicine (CAM) to manage these complex challenges during this life stage. Given the multifaceted nature of these health concerns, an integrated approach that combines dietary supplements with conventional medicine and harnesses nutrient synergy for enhanced benefits should be considered. This article examines current evidence on the use of multivitamins, minerals and dietary supplements (including those containing phytonutrients and other CAMs) for health issues during early midlife and the menopausal transition. Although current evidence suggests that multi-nutrient dietary supplementation combinations are promising, further research is needed to verify their effectiveness and evaluate potential interactions with standard treatments across diverse populations. The successful integration of dietary supplements alongside conventional medicine during the menopausal transition will also require personalized care, support from healthcare professionals and public education.