Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence-Assisted Design of Plant-Protein Meat Analogues: Integrating Nutrition, Functionality, and Fibrillation-Based Texturization.

Comprehensive reviews in food science and food safety·2026
Same author

Size-Selective FET Sensors Based on Semiconducting Single-Walled Carbon Nanotubes and Metal-Organic Frameworks.

ACS applied materials & interfaces·2026
Same author

Carbohydrate-Protein Hydrogels as Fat Replacers: Design Criteria and Benchmarking Against Full-Fat Systems.

Comprehensive reviews in food science and food safety·2026
Same author

Single-cell proteins: fermentation pathways, nutritional quality and digestibility, and a techno-economic and environmental outlook for sustainable scale-up.

Critical reviews in food science and nutrition·2025
Same author

Digital twin for the analog scoliometer: advancements in telehealth for paediatric spine deformity care.

Scientific reports·2025
Same author

Expression and characterization of SARS-CoV-2 spike protein in Thermothelomyces heterothallica C1.

Vaccine·2025

Related Experiment Video

Updated: Jan 12, 2026

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.7K

Monitoring Vaccine-Induced Antibody Levels Using Carbon Nanotube-Based Field-Effect Transistors.

Amir Amiri1, Wenting Shao1, Zidao Zeng1

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Analytical Chemistry
|November 3, 2025
PubMed
Summary

A new biosensor using carbon nanotubes rapidly detects vaccine-induced antibodies. This technology offers a low-cost, convenient method for monitoring immune response and ensuring vaccine effectiveness against infectious diseases.

More Related Videos

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.1K

Related Experiment Videos

Last Updated: Jan 12, 2026

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
12:20

Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions

Published on: July 22, 2013

18.7K
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.1K

Area of Science:

  • Nanotechnology
  • Biosensors
  • Immunology

Background:

  • Vaccines induce antibodies for protection against pathogens, necessitating antibody level monitoring.
  • Current antibody detection methods are inefficient, requiring improved technologies.
  • Developing rapid, convenient, and cost-effective antibody monitoring is crucial for public health.

Purpose of the Study:

  • To develop a novel field-effect transistor (FET) biosensor for rapid and convenient detection of pathogen-specific antibodies.
  • To utilize antigen-functionalized semiconducting single-walled carbon nanotubes (SWCNTs) for enhanced antibody sensing.
  • To validate the sensor's performance for monitoring vaccine-induced antibody levels.

Main Methods:

  • Fabrication of a FET biosensor platform using antigen-functionalized SWCNTs.
  • Characterization of the SWCNT FET biosensor using AFM, SEM, Raman spectroscopy, and FET measurements.
  • Detection of virus-specific antibodies (anti-hemagglutinin, anti-SARS-CoV-2 nucleocapsid, anti-SARS-CoV-2 spike) using the biosensor.

Main Results:

  • The SWCNT FET biosensor demonstrated robust signals with high signal-to-noise ratios upon antigen-antibody interactions.
  • The sensor successfully detected various virus-specific antibodies in different systems.
  • Achieved a wide linear concentration range (100 ag/mL to 100 ng/mL) and low limits of detection (0.20 ag/mL for anti-HA, 20.6 ag/mL for anti-S).

Conclusions:

  • The developed SWCNT FET biosensor platform enables rapid, convenient, and sensitive detection of vaccine-induced antibodies.
  • This nanoelectronic sensor offers a next-generation solution for low-cost antibody monitoring.
  • The technology has the potential to significantly improve vaccine effectiveness surveillance and compliance.