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Updated: Jan 12, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Structural immunotherapy: Harnessing chemical design to build powerful next-generation therapeutics
Michelle H Teplensky1, Julianna N Bourgeois2,3, Sergej Kudruk3,4
1Department of Biomedical Engineering, Boston University, Boston, MA 02215.
None:
Structural immunotherapy relies on the structural features of immunotherapeutics in addition to component identity to influence biodistribution, intra- or extracellular localization, target engagement, and processing kinetics. This strategy is poised to redefine how immunotherapeutics mobilize immunity against disease and transform our ability to harness structure-function relationships to enhance clinical outcomes.
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