Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

705
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
705
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

951
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
951
Drug Delivery: Overview01:16

Drug Delivery: Overview

714
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
714

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cuttlefish Ink-Derived Melanin Nanoparticles Enabling NIR-Responsive Electrospun Nanofibrous Mats for On-Demand Selective Antibacterial Disinfection of Orthodontic Braces.

ACS applied materials & interfaces·2026
Same author

Electrostatic Cell Trapping for Enhanced Sample Yield in Brush Cytology.

ACS applied materials & interfaces·2026
Same author

Microfluidic-Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo-Lysosomal Trafficking Optimization.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Natural melanin: a multifunctional biopigment for advanced biomedical applications.

Progress in biomedical engineering (Bristol, England)·2025
Same author

Transdermal Drug Delivery Systems Powered by Artificial Intelligence.

Advanced healthcare materials·2025
Same author

"Green" Cross-Linking of Poly(Vinyl Alcohol)-Based Nanostructured Biomaterials: From Eco-Friendly Approaches to Practical Applications.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2025

Related Experiment Video

Updated: Jan 12, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.7K

Hydrogel-based ocular drug delivery systems.

Farzaneh Sabbagh1, Seyed Shahrooz Zargarian1, Alicja Kosik-Kozioł1

  • 1Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, 02-106 Warsaw, Poland. fsabbagh@ippt.pan.pl.

Journal of Materials Chemistry. B
|November 3, 2025
PubMed
Summary
This summary is machine-generated.

Hydrogels offer a promising solution for ocular drug delivery, overcoming biological barriers to improve drug bioavailability and enable sustained release for conditions like glaucoma and macular degeneration.

More Related Videos

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.7K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

873

Related Experiment Videos

Last Updated: Jan 12, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.7K
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.7K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

873

Area of Science:

  • Ophthalmology and Biomaterials Science

Background:

  • Ocular drug delivery faces significant challenges due to the corneal epithelium and blood-retinal barrier, leading to low drug bioavailability (<5%) and rapid degradation.
  • Existing treatments often fail to achieve therapeutic drug concentrations in the eye, necessitating innovative delivery systems.

Purpose of the Study:

  • To review the potential of hydrogel-based systems for enhancing drug delivery to both anterior and posterior segments of the eye.
  • To assess hydrogel fabrication methods, characterization techniques, and their application in ocular therapeutics.

Main Methods:

  • Exploration of hydrogel physicochemical properties (swelling, rheology) and drug release kinetics.
  • Review of hydrogel fabrication techniques including chemical crosslinking and 3D printing.
  • Analysis of characterization approaches for mechanical stability and regulatory compliance.

Main Results:

  • Hydrogels demonstrate controlled release, mucoadhesion, and biocompatibility, enabling prolonged ocular drug delivery.
  • Commercial products like DEXTENZA® and ReSure® Sealant showcase hydrogel efficacy in corneal sealing and inflammation control.
  • Emerging technologies include bioengineered hydrogels for retinal regeneration, nanotech integration, and stimuli-responsive systems for glaucoma.

Conclusions:

  • Hydrogels show significant promise for minimally invasive ocular treatments, improving clinical outcomes and patient compliance.
  • Addressing challenges in scalability and production costs is crucial for widespread adoption.
  • Hydrogels are pivotal for advancing treatments for glaucoma, age-related macular degeneration, and dry eye syndrome.