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Updated: Jan 12, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Therapeutic approaches to addressing drug resistance by targeting membranes and associated structures
Shaoqing Du1, Luis Menéndez-Arias2, Xueping Hu3
1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, PR China; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, PR China.
Abstract:
The cell membrane has a pivotal role in cellular activities, such as substance exchange and information transmission. Its dysfunction is closely linked to numerous diseases, positioning it as a vital target for pharmacological interventions. The unique structure of the phospholipids of the membrane, along with its associated proteins, renders it an optimal target for therapeutic interventions designed to combat drug-resistant pathogens. Here, we delve into various advanced mechanisms of action associated with targeted membrane strategies. We also discuss the challenges and future prospects related to these strategies, emphasizing that the integration of various technologies into experimental practices will be a crucial direction for future development.
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