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Updated: Jan 12, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Advances in copper complexes in cancer treatment
Lucía M Balsa1, Lucía Santa Maria de la Parra1, Olivia Espindola-Moreno1
1CEQUINOR (UNLP, CCT-CONICET La Plata, asociado a CIC), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Blvd. 120 N 1465, La Plata 1900, Argentina.
None:
Copper complexes are a class of anticancer compounds studied for the treatment of various types of solid tumors, such as breast, lung, bone, prostate, and ovarian tumors, among others. These compounds have several effects on tumor cell death mechanisms, including apoptosis, necrosis, ferroptosis, and cuproptosis. The chemistry and anticancer activity of copper-based complexes are summarized in this review based on preclinical and clinical research that focuses on structure-activity relationships, molecular targets, and investigation of the mechanism of action and cell death underlying their anticancer activity.
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