Impact of maternal body mass index and gestational comorbidities on the birth prevalence of orofacial clefts in the Japan Environment and Children's Study
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View abstract on PubMed
Summary
This summary is machine-generated.High maternal BMI before pregnancy increases cleft lip and/or palate (CL/P) risk. This risk is further elevated when combined with gestational hypertension or diabetes, highlighting the impact of maternal health on birth defects.
Area Of Science
- Reproductive Health
- Pediatric Health
- Public Health
Background
- Elevated pre-pregnancy body mass index (BMI) is linked to increased cleft lip and/or palate (CL/P) prevalence.
- Gestational comorbidities like hypertension and diabetes also elevate CL/P risk.
- The combined impact of high BMI and these comorbidities on CL/P birth prevalence is not well understood.
Purpose Of The Study
- To investigate the combined effects of pre-pregnancy BMI and gestational comorbidities on CL/P birth prevalence.
- To analyze the association between maternal health conditions and CL/P in offspring.
Main Methods
- Utilized data from 98,373 live births in the Japan Environment and Children's Study (JECS).
- Included 255 mothers of infants with CL/P (cleft lip, cleft lip and palate, isolated cleft palate).
- Employed multivariate logistic regression, adjusting for maternal and child variables, to assess associations.
Main Results
- Mothers of infants with CL/P showed higher rates of overweight, gestational hypertension, and gestational diabetes mellitus.
- High pre-pregnancy BMI significantly increased the odds of CL/P (OR 1.58).
- Combined high BMI with gestational hypertension (OR 2.91) and diabetes (OR 2.12) further elevated CL/P odds.
Conclusions
- High maternal BMI is significantly associated with increased CL/P prevalence.
- Gestational hypertension co-occurring with high maternal BMI poses a substantial risk for CL/P.
- Maternal health status before and during pregnancy critically influences offspring CL/P risk.
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