[Research progress in animal models of pulpitis].

Area of Science:

• Dentistry
• Inflammatory Diseases
• Animal Modeling

Background:

• Pulpitis is a common dental issue, often treated with root canal therapy.
• Root canal therapy can decrease tooth strength and lead to complications.
• Vital pulp therapy (VPT) is a promising alternative but requires accurate pulp status assessment, which current methods lack.

Purpose of the Study:

• To systematically review and summarize methods for creating and evaluating animal models of pulpitis.
• To provide guidance on selecting appropriate animal species and constructing reliable pulpitis models.
• To aid in the development of diagnostic biomarkers and optimization of VPT strategies.

Main Methods:

• Systematic review of literature on pulpitis animal models.
• Analysis of animal selection criteria based on anatomical and pathological relevance.
• Evaluation of model construction techniques and multimodal assessment systems.

Main Results:

• Identified key considerations for selecting animal models for pulpitis research.
• Summarized various methods for inducing and evaluating pulpitis in experimental animals.
• Highlighted the importance of multimodal evaluation for model validation.

Conclusions:

• Appropriate animal models are critical for understanding pulpitis pathogenesis and improving VPT.
• Standardized approaches to animal model development and evaluation are needed.
• This review offers a framework for establishing robust pulpitis animal models to advance dental research and treatment.