Related Experiment Video
Updated: Jan 12, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
895
Managing obesity in older adults
Shyam Sundaresh1, Sara Saliba2, Farah Ziyadeh3
1Assistant Professor, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY shyam.sundaresh@mountsinai.org.
Cleveland Clinic Journal of Medicine
|November 3, 2025
Summary
Managing obesity in older adults requires addressing challenges like sarcopenia and multimorbidity. Key strategies include adequate protein intake, strength training adapted to mobility, and considering medications or surgery for select individuals.
Area of Science:
- Gerontology
- Obesity Medicine
- Metabolic Health
Background:
- Obesity management in older adults presents unique challenges.
- These include multimorbidity, polypharmacy, reduced mobility, and sarcopenia.
- Sarcopenia, age-related muscle loss, is worsened by weight loss.
Purpose of the Study:
- To outline management strategies for obesity in the elderly population.
- To highlight specific considerations for this demographic.
- To discuss the role of lifestyle interventions, medications, and surgery.
Main Methods:
- Review of current literature and clinical guidelines.
- Emphasis on tailored lifestyle modifications.
- Consideration of pharmacotherapy and bariatric surgery.
Main Results:
- Lifestyle interventions should focus on adequate protein intake and exercise.
- Strength training, adapted for mobility, is crucial.
- Antiobesity medications and metabolic-bariatric surgery are options for specific patients.
Conclusions:
- Effective obesity management in older adults necessitates a multifactorial approach.
- Personalized strategies are essential to mitigate risks and optimize outcomes.
- Integrating nutrition, exercise, and potentially medical or surgical interventions is key.
Related Concept Videos
01:21Drug Dosing: Obese Patients
216
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
216
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
233
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
233
01:15Drug Dosing: Geriatric Patients
217
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
217
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:26Atherosclerosis III: Management
311
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
311
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
164
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
164