Related Experiment Video
Updated: Jan 12, 2026
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Thrombotic microangiopathy associated with mantle cell lymphoma: a case report
Yuri Tonouchi1, Koji Hashimoto2, Ryohei Iwabuchi1
1Department of Nephrology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
Background:
Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.
Case Presentation:
A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.
Conclusions:
To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.
