Related Experiment Video

Updated: Jan 12, 2026

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.0K

Associations of the Charlson comorbidity index with asthma and mortality (NHANES 2007-2018): a cross-sectional study

Jia Zhang1, Huan Chen1, Jin Liu1

  • 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi, P.R. China.

Journal of Health, Population, and Nutrition
|November 4, 2025
PubMed

Insights

Comorbidities, measured by the Charlson Comorbidity Index (CCI), are linked to asthma risk. A higher CCI score, especially with asthma, significantly increases the risk of all-cause mortality.

Area of Science:

  • Epidemiology
  • Pulmonology
  • Gerontology

Background:

  • Asthma frequently co-occurs with other health conditions, worsening severity and increasing mortality risk.
  • The Charlson Comorbidity Index (CCI) is a tool to measure comorbid conditions.

Purpose of the Study:

  • To examine the association between the CCI and asthma.
  • To investigate the combined impact of CCI and asthma on all-cause mortality.

Main Methods:

  • Observational, cross-sectional study using NHANES data (2007-2018) of 26,002 adults.
  • Logistic regression for CCI-asthma relationship; survival analysis (Kaplan-Meier, Cox regression) for mortality impact.
  • Subgroup analyses were conducted to validate findings.

Main Results:

  • An association was found between CCI and asthma (OR, 1.120).
  • Higher CCI scores correlated with increased mortality risk (HR, 1.143).
  • Individuals with both asthma and CCI score ≥2 faced substantially higher mortality risk (HR, 1.853) compared to those with no asthma and CCI score of 0.

Conclusions:

  • The CCI is associated with asthma risk and elevated all-cause mortality.
  • Further research is needed to understand the causal link between CCI, asthma, and mortality.
Abstract

Keywords:
AsthmaCCIComorbidityMortalityNHANES

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.2K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.1K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.2K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.1K