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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia: An Uncommon Clinical Challenge
Rafaela Faria1, Leticia Balanco2, Vânia Almeida3
1Orthopaedics, Unidade Local de Saúde da Região de Leiria, Leiria, PRT.
Cureus
|November 4, 2025
Summary
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare lung disease. Early suspicion and histopathological confirmation are crucial for diagnosis, with somatostatin analogues showing promise in selected patients.
Area of Science:
- Pulmonary Medicine
- Oncology
- Radiology
Background:
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare interstitial lung disease.
- It is characterized by diffuse proliferation of neuroendocrine cells, considered a preneoplastic condition.
- DIPNECH often affects non-smoking women and presents with insidious symptoms, leading to diagnostic delays.
Keywords:
diffuse idiopathic pulmonary neuroendocrine cell hyperplasiadipnechinterstitial lung diseaselanreotidelung biopsysomatostatin analoguesvatsvideo-assisted thoracoscopic surgeryMore Related Videos
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