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Marjolin Ulcer: Squamous Cell Carcinoma Arising in a Modeling Agent-Induced Ulcer
Naomi H Domínguez-Wakida1, Azyadeth Gracián-Castro1, Marcela Hernández-Vera1
1Dermatology, Hospital General "Dr. Manuel Gea González", Mexico City, MEX.
Cureus
|November 4, 2025
Summary
Mineral oil injections can cause chronic leg ulcers that may rarely transform into squamous cell carcinoma. Close monitoring of these ulcers is crucial, especially in patients with a history of using unregulated modeling agents.
Area of Science:
- Dermatology
- Oncology
Background:
- Mineral oil injections, used as modeling substances, can lead to chronic inflammation and persistent ulceration.
- These chronic lesions carry a rare risk of malignant transformation into aggressive cutaneous neoplasms, such as Marjolin ulcers.

