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Updated: Jan 12, 2026

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Syntheses of Quaternary Carboxylic Acid Derivatives via a Photo-Wolff Rearrangement/Pd Catalysis Sequence
Yi-Peng Wang1, Binghua Zhao1, Nannan Wang1
1Technical Institute of Fluorochemistry (TIF), Institute of Advanced Synthesis (IAS), State Key Laboratory of Material-Oriented Chemical Engineering, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China.
None:
Expedient synthesis of two types of quaternary carboxylic acid derivatives from α-carbonyl diazo substrates was established via a sequential photo-Wolff rearrangement/Pd-catalyzed difunctionalization of ketene. Allyl oxyphthalimide was used for the first time as a bifunctional allylating reagent to provide access to quaternary redox-active esters. A three-component reaction with allyl chloride as an allylating reagent in the presence of an external nucleophile was also accomplished to afford quaternary esters.
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