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Maternal risk factors and closure techniques in gastroschisis: a 16-year retrospective review from a UK tertiary

A Anand1, A M Masna2, A Kulkarni2

  • 1Monash Health, Melbourne, Australia.

Pediatric Surgery International
|November 4, 2025
PubMed

Insights

Sutureless closure for gastroschisis (a congenital abdominal wall defect) may speed feeding but increases sepsis and hernia risks. Maternal smoking independently raises neonatal sepsis risk.

Area of Science:

  • Pediatric Surgery
  • Neonatal Care
  • Congenital Abnormalities

Background:

  • Gastroschisis is a congenital defect requiring surgical intervention.
  • Early outcomes and risk factors associated with gastroschisis management are crucial for improving infant survival and well-being.

Purpose of the Study:

  • To evaluate early outcomes in infants with gastroschisis.
  • To analyze associations between maternal factors, surgical closure techniques, and postoperative complications.

Main Methods:

  • Retrospective cohort study of 126 infants with gastroschisis (2008-2024).
  • Data collected on maternal demographics, perinatal factors, and surgical management.
  • Multivariable logistic regression adjusted for key infant and maternal variables.

Main Results:

  • Sutureless closure showed trends toward earlier feeding and shorter hospital stays but was linked to higher sepsis (73% vs. 41%) and hernia rates (42% vs. 22%).
  • Maternal smoking was an independent risk factor for neonatal sepsis (adjusted OR 2.1).
  • Overall survival was 96.8%, with deaths in complex cases.

Conclusions:

  • Sutureless closure may have perioperative benefits but increases postoperative morbidity.
  • Maternal smoking is a modifiable risk factor for neonatal sepsis.
  • Individualized surgical strategies and targeted maternal interventions are recommended for gastroschisis management.
Abstract

Keywords:
GastroschisisHernia FormationMaternal SmokingNeonatal SepsisNeonatal SurgerySutureless Closure

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