Related Experiment Video
Updated: Jan 12, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Clonal cytogenetic abnormality in IgG4-related disease
Prasad Koduru1, Sara Monaghan2, Rolando Garcia1
1Department of Pathology, UT Southwestern Medical Center, Dallas, TX.
Abstract:
Inflammatory conditions in which immunoglobulin G4 secreting plasma cells infiltrate the affected tissue and form a systemic immune-mediated fibroinflammatory lesion is recognized as IgG4+ related disease. Patients with this disease are at an increased risk for developing neoplasm. Lymphadenopathy is common in patients with IgG4+ related disease; and may clinically resemble lymphoma. Here we describe a patient presented with an IgG4+ related lymphadenopathy (disease) and harbored a clonal cytogenetic abnormality; to our knowledge this is the first report.
More Related Videos
09:35Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
Published on: April 20, 2021
15:07VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Related Concept Videos
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response