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Updated: Jan 12, 2026

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Plant-derived Bioactive Substances with Anti-rheumatoid Arthritis Properties.

Haoyue Jiang1,2, Ze Sun1,2, Xiaoya Zhao1,2

  • 1College of Life Science, Liaoning University, Shenyang, China.

Planta Medica
|November 4, 2025
PubMed
Summary
This summary is machine-generated.

Plant-derived bioactive compounds show promise for managing rheumatoid arthritis (RA), a chronic autoimmune condition. This review highlights their potential anti-arthritic properties and mechanisms for future therapeutic strategies.

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Area of Science:

  • Pharmacology and Natural Products Chemistry
  • Immunology and Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint inflammation, fluid accumulation, and cartilage damage.
  • RA can lead to joint deformity, impaired function, and reduced quality of life, with incidence increasing with age.
  • Current treatments cannot cure RA, necessitating strategies to delay disease progression.

Purpose of the Study:

  • To systematically review plant-derived bioactive substances with anti-arthritic properties.
  • To elucidate the mechanisms of action of these compounds in preventing and treating rheumatoid arthritis.
  • To provide a reference for developing novel therapeutic strategies for RA.

Main Methods:

  • Comprehensive literature search for studies on plant-derived bioactive substances and rheumatoid arthritis.
  • Systematic evaluation of anti-arthritic properties of identified compounds.
  • Focus on specific classes: flavonoids, polyphenols, terpenes, alkaloids, phenols, quinones, and phenylpropanoids.

Main Results:

  • Plant-derived bioactive substances demonstrate significant potential in preventing and managing rheumatoid arthritis.
  • Various compound classes, including flavonoids and polyphenols, exhibit anti-arthritic activities.
  • Elucidation of mechanisms of action provides insights into therapeutic potential.

Conclusions:

  • Plant-derived bioactive substances offer a promising avenue for the prevention and treatment of rheumatoid arthritis.
  • Further research into these compounds and their mechanisms can lead to novel therapeutic interventions for RA.
  • These natural compounds represent a valuable resource for managing this chronic autoimmune disease.