Related Experiment Video
Updated: Jun 29, 2026
12:17
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
11.1K
Maternal exercise alters placental proteome in an exercise mode-specific manner
Filip Jevtovic1,2,3,4, Breanna L Wisseman1,2,3,5, Fahmida Jahan4
1Department of Kinesiology, East Carolina University, Greenville, North Carolina, United States.
American Journal of Physiology. Endocrinology and Metabolism
|November 4, 2025
Summary
Maternal exercise, including aerobic and resistance training, significantly alters placental proteins. The type and volume of exercise impact placental proteome, influencing maternal and infant health.
Area of Science:
- Reproductive Biology
- Metabolic Health
- Proteomics
Background:
- Maternal exercise improves gestational and infant metabolic health.
- Different exercise modes' effects on the placenta are understudied.
- The placenta is crucial for maternal-fetal communication.
Purpose of the Study:
- To characterize placental proteomic changes due to supervised maternal exercise.
- To investigate exercise mode-specific effects on the placenta.
- To determine the association between exercise volume and placental proteins.
Main Methods:
- Controlled, supervised maternal exercise interventions during gestation.
- Placental tissue collection and proteomic analysis.
- Statistical analysis to identify differentially expressed proteins.
Main Results:
- Placental proteomic landscape changes are specific to maternal exercise mode.
- Approximately 20-25% of identified placental proteins correlate with maternal exercise volume.
- Significant alterations in placental proteins observed in response to exercise.
Conclusions:
- Maternal exercise modes differentially impact the placental proteome.
- Placental function is influenced by both the type and amount of maternal exercise.
- The placenta mediates maternal exercise effects on maternal and infant health.
More Related Videos
08:04Measuring Mitochondrial Electron Transfer Complexes in Previously Frozen Cardiac Tissue from the Offspring of Sow: A Model to Assess Exercise-Induced Mitochondrial Bioenergetics Changes
Published on: August 16, 2021
2.9K
05:17Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
Published on: April 5, 2024
1.3K
Related Concept Videos
03:17Inheritance of Chromatin Structures
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
02:59Animal Mitochondrial Genetics
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
01:58Cell Specific Gene Expression
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
01:28Forced Transdifferentiation
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Artificial transdifferentiation occurs...
01:24Methods of Nuclear Reprogramming
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
00:57Cellular Differentiation
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...