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BDNF gene polymorphisms and substance use disorders: a systematic review

Danil Peregud1,2, Valeria Baronets1, Olga Pavlova1

  • 1Federal State Budgetary Institution "V. Serbsky National Medical Research Centre for Psychiatry and Narcology" of the Ministry of Health of the Russian Federation, Kropotkinsky ln. 23, Moscow 119034, Russia.

Reviews in the Neurosciences
|November 4, 2025
PubMed
Summary

Genetic factors influence substance use disorders (SUDs). Variations in the Brain-Derived Neurotrophic Factor (BDNF) gene, particularly the rs6265 polymorphism, show associations with SUD risk and clinical outcomes.

Keywords:
brain-derived neurotrophic factorpsychoactive substancessingle nucleotide polymorphismssubstance use disorders

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