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Non-Wire Bracketed Localization Techniques and Decreased Margin Positive Rates in Breast Cancer.

Nicole Harris1, Paige Aiello1, David Detz1

  • 1H. Lee Moffitt Cancer Center,Department of Breast Oncology, Tampa, FL.

Clinical Breast Cancer
|November 4, 2025
PubMed
Summary
This summary is machine-generated.

Non-wire localization devices like electromagnetic clips (EMC) and radar localization (RL) improve breast-conserving therapy (BCT) outcomes. These methods reduce positive margins and operative times compared to traditional wire localization for bracketed BCT.

Keywords:
Bracketed localizationBreast conserving surgeryMargin statusMultifocal breast cancerNon wire localization

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiology

Background:

  • Breast-conserving therapy (BCT) for nonpalpable lesions often requires localization devices.
  • For larger or multifocal lesions, multiple localizers (
  • bracketing
  • ) are necessary for complete excision.
  • Traditional wire localization can be challenging for complex cases.

Purpose of the Study:

  • To compare the efficacy of non-wire localization devices, specifically electromagnetic clips (EMC) and radar localization (RL), against traditional wire localization in bracketed BCT.
  • To evaluate differences in positive margin rates, operative times, and localizer retrieval between these methods.

Main Methods:

  • A retrospective study analyzed 118 bracketed BCT cases from August 2020 to August 2024.
  • Cases were categorized into wire localization, RL, and EMC groups.
  • Outcomes assessed included case length, positive margins requiring re-excision, and complete localizer retrieval, with statistical analysis using Kruskal-Wallis and chi-squared/Fisher's exact tests.

Main Results:

  • Fewer positive margins were observed with EMC (29%) and RL (22.7%) compared to wire localization (50%) (P = .022).
  • Electromagnetic clip (EMC) cases had significantly shorter operative times (33.9 minutes) than RL (45.6 minutes) and wire localization (40 minutes) (P = .025).
  • Complete localizer retrieval rates were high across all groups (EMC 93.5%, RL 97.7%, wire 100%), with no significant difference (P = .264).

Conclusions:

  • Non-wire localization, particularly EMC, is effective for bracketed BCT, demonstrating lower positive margin rates and reduced operative times.
  • These findings support the adoption of EMC and RL in breast-conserving surgery, especially for cases requiring multiple localizers.