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Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO
Pascale Bémer1, Chloé Plouzeau-Jayle2, Carole Lemarié3
1Service de Bactériologie et des Contrôles Microbiologiques, CHU Nantes, Nantes, France.
Abstract:
Diagnosis of prosthetic Joint Infections (PJI) remains challenging at the microbiological level. Despite the implementation and adoption of new methods, an heterogeniety of microbiological practices is still observed. These CRIOGO recommendations (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest) aim to set out some basic principles for the diagnosis of PJI in microbiology laboratories. The CRIOGO microbiologists' team who have been working together for 15 years were invited to provide regional recommendations for microbiology diagnosis based on their practical expertise. These recommendations were developed through a systematic review of the literature and discussion amongst experts. The proposed CRIOGO recommendations were voted on upon by a 10 local panelists via the Delphi process. Total consensus was reached on all 27 recommendations that received 100% agreement. The CRIOGO microbiologists' team proposed practical guidelines in response to the most frequently asked questions received at our laboratory reference centres. A short, comprehensive answer supported by literature backs up the argument. Out of the 27 detailed CRIOGO recommendations, 22 achieved 100% consensus. This work was initiated to harmonise our daily practices for managing PJI diagnosis within the CRIOGO network in line with the literature.
Insights
Microbiologists developed practical guidelines to improve prosthetic joint infection (PJI) diagnosis in laboratories. These recommendations aim to standardize PJI diagnostic practices, ensuring consistency and accuracy in clinical microbiology.
Area of Science:
- Microbiology
- Infectious Diseases
- Orthopedics
Background:
- Diagnosing prosthetic joint infections (PJI) presents microbiological challenges.
- Heterogeneity in microbiological practices hinders consistent PJI diagnosis.
- Existing diagnostic methods require standardization for improved patient outcomes.
Purpose of the Study:
- To establish regional recommendations for microbiological diagnosis of PJI.
- To harmonize daily practices for PJI diagnosis within the CRIOGO network.
- To provide evidence-based guidelines addressing common laboratory diagnostic questions.
Main Methods:
- Systematic literature review and expert discussion.
- Delphi process involving 10 local panelists.
- Development of 27 consensus-based recommendations for PJI microbiology.
Main Results:
- 27 practical recommendations for PJI microbiological diagnosis were proposed.
- 22 recommendations achieved 100% consensus among experts.
- Guidelines were developed based on practical expertise and literature review.
Conclusions:
- The CRIOGO recommendations provide a framework for standardized PJI microbiological diagnosis.
- Harmonized practices are crucial for accurate and reliable PJI diagnosis.
- These guidelines aim to improve the management of PJI in clinical microbiology laboratories.
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