Non-linear relationship between the triglyceride glucose-a body shape index and stroke risk: a prospective cohort...

Recent evidence suggests a strong association between triglyceride glucose-a body shape index (TyG-ABSI) and cardiovascular mortality. However, the association between TyG-ABSI and incident stroke has not been explored. Our study utilized a prospective cohort design to explore the potential association between TyG-ABSI and incident stroke within a Chinese population.

A total of 8,715 subjects from the China Health and Retirement Longitudinal Study were included in this analysis, categorized into stroke (n = 805) and non-stroke (n = 7,910) groups. To assess the association between TyG-ABSI and incident stroke, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroup analyses, and sensitivity analyses.

The mean age of participants was significantly higher in the stroke group (61.26 ± 8.42 years) compared to the non-stroke group (59.14 ± 9.27 years). Multivariate analysis revealed that higher TyG-ABSI was significantly associated with increased stroke risk, with an HR of 1.22 (95% CI: 1.09-1.37, P = 0.0004). Notably, this association between TyG-ABSI and incident stroke was non-linear, and a significant inflection point was identified at a TyG-ABSI of 6.42. The HR to the left and right of this inflection point were 2.44 (95%CI: 1.19-5.02, P = 0.0151) and 1.16 (95%CI: 1.02-1.31, P = 0.0239), respectively. Subgroup and sensitivity analyses further validated the robustness of the association between TyG-ABSI and incident stroke.

Our analysis revealed a non-linear positive association between TyG-ABSI and incident stroke. These findings emphasize the necessity of incorporating TyG-ABSI monitoring into clinical practice to identify individuals at greater risk for stroke.