Association between renal function and simple renal cyst growth: a retrospective study.

Area of Science:

• Nephrology
• Urology
• Radiology

Background:

• Simple renal cysts (SRC) are common and often associated with proteinuria and renal insufficiency.
• The influence of renal function, specifically estimated glomerular filtration rate (eGFR), on SRC size and growth is not well-established.

Purpose of the Study:

• To investigate the impact of renal function, measured by eGFR, on the size and growth rate of simple renal cysts.

Main Methods:

• Retrospective study of 502 patients with SRC diagnosed between August 2019 and February 2022.
• Follow-up data from 185 patients included B-ultrasound monitoring of SRC size and growth.
• Analysis of the relationship between eGFR levels and SRC characteristics using linear and logistic regression.

Main Results:

• Patients with lower eGFR exhibited significantly larger SRC sizes and higher growth rates.
• Low eGFR levels correlated with increased risk of larger maximum SRC volume and faster growth.
• Multivariate analysis confirmed that reduced eGFR is associated with larger SRC size and accelerated growth.

Conclusions:

• Renal function, indicated by eGFR, shows an inverse relationship with both SRC size and growth rate.
• Close monitoring of renal function in patients with low eGFR is recommended for early detection and management of SRC progression.