Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.1K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.6K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

273
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
273
Coagulation01:09

Coagulation

9.6K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.6K
Coagulation01:06

Coagulation

1.2K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.2K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.0K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Commentary on Severe Thrombocytopenia Complicating Iron Deficiency Anemia: A Diagnostic Challenge?

The journal of applied laboratory medicine·2026
Same author

Over-the-Counter Loperamide Overdose Resulting in Cardiac Arrest.

JACC. Case reports·2026
Same author

A Diagnostic Journey through a Rare Hemostatic Disorder.

The journal of applied laboratory medicine·2026
Same author

A Practical Guide to Advancing Your Career: Laboratory Medicine Maxims.

The journal of applied laboratory medicine·2026
Same author

Abstracts from the 2025 ADLM Preanalytical Phase Conference-Advancing Preanalytics: From Innovative Breakthroughs to Practical Applications.

The journal of applied laboratory medicine·2026
Same author

Simulated Microgravity Causes Delayed Platelet Activation and Downregulates Acid-Sensing Ion Channel 1/2 Protein Expression.

Biomedicines·2025

Related Experiment Video

Updated: Jan 12, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.1K

ADLM Guidance Document on Coagulation Testing in Patients Using Direct Oral Anticoagulants.

Lindsay A L Bazydlo1, Maximo J Marin2, Anna E Merrill3

  • 1Department of Pathology, University of Virginia, Charlottesville, VA, United States.

The Journal of Applied Laboratory Medicine
|November 5, 2025
PubMed
Summary

Direct oral anticoagulants (DOACs) simplify treatment but impact coagulation tests. This guide helps interpret results and manage testing for patients on DOACs, ensuring accurate hemostasis assessment.

More Related Videos

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.3K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.4K

Related Experiment Videos

Last Updated: Jan 12, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.1K
Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

14.3K
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.4K

Area of Science:

  • Clinical Chemistry
  • Hematology
  • Pharmacology

Background:

  • Coagulation testing is vital for diagnosing and managing hemostasis disorders.
  • Direct oral anticoagulants (DOACs) offer convenient anticoagulation but present challenges for standard laboratory testing.
  • Understanding DOAC interference is crucial for accurate patient assessment.

Purpose of the Study:

  • To provide guidance on coagulation tests affected by DOACs.
  • To discuss methods for mitigating DOAC interference in testing.
  • To outline strategies for testing and interpreting DOAC concentrations.

Main Methods:

  • Literature review of DOAC impact on coagulation assays.
  • Analysis of specific coagulation tests and their susceptibility to DOACs.
  • Evaluation of mitigation strategies and concentration testing.

Main Results:

  • Certain coagulation tests are significantly impacted by DOACs, potentially leading to inaccurate results.
  • Specific protocols can mitigate DOAC interference, allowing for reliable testing.
  • Methods exist to quantify DOAC concentrations for clinical interpretation.

Conclusions:

  • Coagulation testing in patients on DOACs requires careful consideration of drug interference.
  • Appropriate testing strategies and interpretation are essential for patient care.
  • This guidance aids clinicians in navigating coagulation testing complexities with DOAC therapy.