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CD30-Positive Lymphoproliferative Disorder With DUSP22-IRF4 Rearrangement and Gamma-Delta T-Cell Phenotype: A Novel
Heidi Bai1, Veronica Voronina2, Aayushma Regmi3
1Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Journal of Cutaneous Pathology
|November 5, 2025
Summary
This case study describes an unusual presentation of lymphomatoid papulosis (LyP) in an elderly patient, characterized by a rare DUSP22-IRF4 gene rearrangement and T-cell receptor gamma-delta phenotype, which resolved spontaneously.
Area of Science:
- Dermatopathology
- Oncology
- Genetics
Background:
- Lymphomatoid papulosis (LyP) is a rare primary cutaneous T-cell lymphoma.
- LyP typically presents as recurrent crops of papules and nodules.
- Diagnosis can be challenging due to histological overlap with other cutaneous lymphomas.
