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Diagnostic Challenges of Thyrotoxicosis in Pregnancy Presenting as Stroke and Hyperemesis Gravidarum

Varsha Pudi1, Kanishka Kamath2, Fatima Kamal2

  • 1Internal Medicine, University of Vermont, Larner College of Medicine, Burlington, USA.

Cureus
|November 5, 2025
PubMed

Hyperthyroidism in pregnancy carries serious risks for both the pregnant individual and the fetus. Presenting symptoms may include fatigue, nausea, and palpitations. Timely diagnosis and intervention are challenging because clinical features overlap with physiological changes in pregnancy. This case report describes a diagnostically challenging presentation of thyrotoxicosis in pregnancy with neurological symptoms mimicking a stroke, which is atypical since stroke-like presentations are not typically associated with hyperthyroidism. This case highlights the importance of maintaining a broad differential in pregnant individuals with persistent, unexplained systemic symptoms.

Keywords:
clinical endocrinologygestational thyrotoxicosisgraves diseasemedical disorders in pregnancytachycardia in pregnancy

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