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Updated: Jan 12, 2026
A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Pathway economy in cyclization of 1,n-enynes
Hezhen Han1,2,3, Wenjie Mao1,2,3, Bin Lin1,2,3
1Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
Abstract:
This review presents a paradigm-shifting "pathway economy" strategy for 1,n-enyne cyclization, enabling divergent construction of complex molecular architectures from a single substrate class. Through mechanistic-guided modulation of catalysts, solvents, ligands, and angle strain, this approach achieves unprecedented reaction pathway control while demonstrating superior temporal and step efficiency compared to conventional methods. The work establishes a sustainable framework for rapid molecular diversification, offering transformative potential for green chemistry and pharmaceutical applications. By unifying mechanistic insights with practical synthetic design, this review provides valuable guidance for future innovations in precision organic synthesis.
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