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Uveal melanoma (UM) can mimic inflammatory conditions, presenting a diagnostic challenge. Early consideration of UM in cases of intraocular inflammatory masses is crucial for timely diagnosis and treatment.

Keywords:
Case reportInflammationMelanomaPRAMEUveaUveitis

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Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Uveal melanoma (UM) is the most common primary intraocular malignancy.
  • While typically diagnosed by characteristic features, UM can present atypically, mimicking inflammatory or infectious processes.

Purpose of the Study:

  • To highlight the diagnostic challenges posed by uveal melanoma presenting as an inflammatory mass.
  • To emphasize the importance of considering UM in the differential diagnosis of intraocular inflammatory conditions.

Main Methods:

  • Presentation of two clinical cases of uveal melanoma initially misdiagnosed as inflammatory or infectious processes.
  • Review of diagnostic considerations for intraocular masses.

Main Results:

  • Both patients presented with intraocular masses initially diagnosed as inflammatory or infectious conditions.
  • Subsequent evaluation revealed the masses to be uveal melanoma.

Conclusions:

  • Uveal melanoma should be included in the differential diagnosis for any intraocular inflammatory mass.
  • Diagnostic tumor biopsy may be necessary for definitive diagnosis of challenging cases.