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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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Minimally Invasive Model of Mitral Regurgitation in Mice

Jian Wu1, Xuan Li1, Xiang Li1,2

  • 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences (J.W., Xuan Li, Xiang Li, J.J., L.K., L.C., C.Y., Z.Z., S.W., H.G., K.C., Y.Z.), Fudan University, China.

Circulation Research
|November 5, 2025
PubMed
Summary

No abstract available in PubMed .

Keywords:
cauteryheart failurehypertrophymicemitral valve insufficiency

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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