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Updated: Jan 12, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Spindle Cell Carcinoma: A Rare and Aggressive Variant of Squamous Cell Carcinoma of the Upper Lip
Prabhat Bhaskarrao Nichkaode1, Rishika Mishra
1Department of Surgery, Dr. D. Y. Patil Medical College and Research Centre, Affiliated to Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Abstract:
Spindle cell carcinoma (SpCC), also known as sarcomatoid carcinoma, is a rare biphasic malignant neoplasm ranging variably from reactive to malignant making it critical and relatively challenging where tumors have areas of squamous cell carcinoma (SCC) admixed with areas of pleomorphic tumor. It is a rare variant of SCC characterized by malignant spindle-shaped cells resembling sarcomas. Spindle cell lesions of the head and neck are diverse with great clinical and biological variety. They tend to show rapid progression with a high recurrence rate and the ability to metastasize, all of which contribute to their poor prognosis.
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