Role of Volumetric Parameters Derived From Ga-68 PSMA PET-CT in Predicting Treatment Response

We aimed to determine whether TL-PSMA, PSMA-TV, and SUVpeak values measured in prostate adenocarcinoma patients who underwent imaging with Ga-68 PSMA PET/CT for primary staging have a role in predicting treatment response.

Images of 68 patients who underwent Ga-68 PSMA PET/CT for primary staging between March 25, 2019, and December 3, 2021, were analyzed retrospectively. Volumetric parameter data were obtained through manual delineation using a 40% threshold for the prostate gland, lymph nodes, bone, and visceral organ metastases.

TL-PSMA(Bone) measurement differed statistically significantly between the treatment-responsive and unresponsive groups (p = 0.049). In addition, TL-PSMA and PSMA-TV parameters showed statistically significant differences between the treatment-responsive and unresponsive groups (p = 0.02 and p = 0.016). We could not find a significant relationship between other volumetric parameters and treatment response.

It has been established that the volumetric parameters derived from Ga-68 PSMA PET/CT imaging conducted for primary staging may play a role in predicting treatment response in patients with prostate adenocarcinoma. However, further studies involving larger patient populations are necessary to clarify this issue.