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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
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Vein bypass versus endovascular treatment for chronic limb ischaemia
Atalel F Awedew1, Feron Getachew2, Mihretu Jegnie3
1Surgery, Debre Tabor University, Debre Tabor, Ethiopia.
The Cochrane Database of Systematic Reviews
|November 5, 2025
Insights
This review compares vein bypass surgery with endovascular treatment for chronic limb ischemia. It aims to determine which treatment offers better benefits and fewer harms for patients.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Evidence-Based Medicine
Background:
- Chronic limb ischemia (CLI) is a severe manifestation of peripheral artery disease (PAD).
- Treatment options for CLI include open surgical bypass and endovascular therapies.
- Optimal treatment strategy for CLI remains debated, necessitating comparative effectiveness research.
Purpose of the Study:
- To systematically review and synthesize evidence comparing vein bypass grafting with endovascular treatment for CLI.
- To evaluate the benefits and harms associated with each treatment modality.
- To inform clinical decision-making and guideline development for CLI management.
Main Methods:
- Cochrane systematic review methodology.
- Inclusion of randomized controlled trials (RCTs) and high-quality observational studies.
- Assessment of clinical outcomes including amputation rates, mortality, morbidity, and quality of life.
Main Results:
- Data synthesis on the comparative efficacy and safety of vein bypass versus endovascular treatment for CLI.
- Identification of patient subgroups who may benefit more from one treatment over the other.
- Analysis of potential trade-offs between short-term and long-term outcomes.
Conclusions:
- Evidence-based conclusions on the relative benefits and harms of vein bypass and endovascular treatment for CLI.
- Recommendations for clinical practice and future research directions.
- Contribution to optimizing patient outcomes in CLI management.
Abstract
Objectives:
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of vein bypass compared with endovascular treatment for chronic limb ischaemia.
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