Related Experiment Video
Updated: Jan 12, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
The functional attributes of co-processed excipients in direct compression
Renate Coetzee1, Josias Hamman1, Jan Steenekamp1
1Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Abstract:
The pharmaceutical industry is increasingly adopting co-processed excipients as alternatives to conventional excipients in tablet manufacturing despite certain regulatory challenges. Co-processing of excipients was designed to optimize physical powder properties such as flowability, compressibility, and compactibility, which are critical attributes for efficient tablet production, especially by means of direct compression. This review summarizes the various preparation methods of co-processed excipients and comprehensively discusses the role of co-processed excipients over conventional pharmaceutical excipients in enhancing tablet formulation as well as tablet manufacturing efficiency and consistency due to their improved functionality. Furthermore, the functionality and enhancement of performance of co-processed excipients are discussed on the three levels of solid substances, namely the molecular, particle and bulk levels. It further evaluates the effectiveness of co-processed excipients in addressing common formulation challenges such as moisture, lubricant sensitivity and strain rate sensitivity.
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Drug Dissolution: Requirements and Profile Comparison

