Electrochemical N-H Phosphorodithiolation of Sulfoximines with P₄S₁₀ and Alcohols

Coupling dithiophosphates with sulfoximines is a promising strategy for generating diverse bioactive products, but a mild and efficient method is highly desirable. Herein, an electrochemical method has been developed to achieve N-H phosphorodithiolation of sulfoximines, providing N-(diethylphosphorodithioate) sulfoximines with moderate to good yields in the absence of external chemical oxidants. Furthermore, this approach can be extended to the synthesis of (dialkylphosphorodithioate) sulfoximines by employing in situ generated dialkylphosphorodithioate from P₄S₁₀ and alcohols in one pot.